We are building a leading microbiome company

We are a committed team of experts seeking to help patients through effective microbiome restoration biotherapeutics

Key Figures

25 AML patients administred in Phase 1b/2a Clinical Trial
160 patients enrolled in our trials overall
7 patent families filed, 1 in-licensed patent
3 Trademarks filed
5 Clinical trials authorized in 2 years
17€ million financing raise
20 employees

Our team comprises of Investors Academics and Strategic Partners, all Microbiome experts, and a team of 20 employees fully committed to the MaaT Pharma project.

Discover Our Team

Our Vision

Become the industry leader for the treatment of Gut Microbiota alteration (Dysbiosis) using patient-specific biotherapeutics in patients with serious medical conditions.

Our Mission

Our initial goal is to develop a series of biotherapeutics aiming to improve the survival outcome of blood cancer. Our revolutionary MaaT Microbiome Restoration Therapy (MMRB) discovery and analysis platform will support the evaluation of drug candidates, the determination of novel disease targets and the identification of biomarkers for microbiome-related conditions.

Our Ecosystem

MaaT Pharma has established several strong business partnerships. We have developed an efficient academic-industry translational collaboration with two entities from INRA (Institut National de la Recherche Agronomique or French National Institute for Agricultural Research): Micalis and MetaGenoPolis to design our proprietary MaaT Microbiome Restoration Platform which is the engine of our drug development platform. We also established a partnership with Biocodex in the area of oral formulation development. These two collaborations have led to the filing of 7 patent families and 1 patent in-license agreement.

The microbiome industry is emerging, especially the notion of developing therapeutics sourced from gut microbiota. As of today, there are three main approaches: Fecal microbiotherapy (via enteral or oral adminstration), microbiota modulators (agonists or antagonists) or molecules mimicking microbial components or products. We compete in the field of developing drugs based on the concept of fecal microbiotherapy using a unique pooled technology allowing very high diversity restoration. This approach has showed the highest efficacy in the therapeutic area of Clostridium difficile.

We have been working in coordination with the French regulatory agency (ANSM) since we designed our initial clinical development program framework in 2014 aiming at evaluating our microbiota-based drugs. Since then, we have extended our discussions at the EMA level as well as local competent national authorities and the FDA, in the USA. As for our medical devices, they were developed in line with the 93/42/CEE directive. We intend to obtain a CE marking for all our devices. To date, our collection device is CE marked, whereas the certification for our class II storage bag and accessories is expected by Q3 -2018.

MaaT Pharma targets to develop products that would be primarily prescribed by physicians in hospitals. We have, to date, completed several clinical trials that were conducted in 12 different hospitals in France where we initially assessed our drug candidates. We are now expanding geographically to 15 additional hospitals in Europe thanks to our clinical trial in acute GvHD.

We are located in the Gerland Biodistrict in Lyon, a vibrant ecosystem composed of leading businesses, SMEs and start-ups, research laboratories, universities and elite institutions, where we have established successful partnerships. We are also a member of the Lyonbiopole Cluster, the gateway to healthcare innovation in the Auvergne-Rhône-Alpes region.

Since our foundation in December 2014, Seventure, a subsidiary of Natixis and the first European fund devoted to microbiome investments “Health for Life”, has been a shareholder along with CM-CIC Innovation, one of the leading financers in high tech companies in France, Biocodex, an independent multinational pharmaceutical leader focused initially on probiotics, and finally the National Institute for Agricultural Research (INRA,) one of the leading academic centers in the field of Microbiota. As of March 2018, MaaT Pharma has raised 12 m€ in equity and 5+ m€ in non-dilutive funding thanks to the support from Bpifrance and our banking pool CIC and BNP Paribas.

Our Team.

Hervé Affagard

Chief Executive Officer – Co founder

As an entrepreneur in residence, Hervé has led MaaT Pharma since its inception phase in 2014. Notably, he was awarded Entrepreneur of the Year in Healthcare (2016) in recognition of his outstanding contribution to the development of MaaT Pharma.

Engineer, Executive MBA, Certificate “Exploring your Microbiome”, Francebiotech

Our Team.

Dr Alain Herrera

Acting Chief Medical Officer

Alain, a Hematologist Consultant at Antoine Beclere Hospital (Paris), brings more than 25 years of experience in the pharmaceutical industry. Notably, he headed the Oncology business at Sanofi-Aventis for 10 years where he contributed to the worldwide registration of several products.

MD, ASCO, ESMO

Siân Crouzet

Chief Operations Officer

Siân has led the Finance and Operational functions at MaaT Pharma since 2016. She has held various finance roles, including 7 years as Principal Financial Officer and Director at Avadel Pharmaceuticals (AVDL) where she was involved in a capital raise of $130 million.

CPA, IFRS Certified

Dr Corentin Le Camus

Therapeutic Development Director

Corentin has led the Clinical operations since 2015. He has international clinical development experience within big pharma companies. He also built up the clinical team at Olympus Biotech from the inception of the company.

PhD, Executive MBA

Dr Carole Schwintner

Pharmaceutical Development Director

Carole has led the Pharmaceutical Development activities since 2014. Previously, she held diverse responsibilities in GMP manufacturing for Biorad as Microbiology Production Director. She was also COO for a start-up company specializing in glycosylated proteins.

PhD, Graduate agronomist specialized in biotechnology

Our Main Co-founders.

Hervé Affagard

Chief Executive Officer – Co founder

As an entrepreneur in residence, Hervé has led MaaT Pharma since its inception phase in 2014. Notably, he was awarded Entrepreneur of the Year in Healthcare (2016) in recognition of his outstanding contribution to the development of MaaT Pharma.

Engineer, Executive MBA, Certificate “Exploring your Microbiome”, Francebiotech

Dr Joël Doré

Scientific Advisor – Co founder

Joël is a worldwide renowned researcher with more than 200 publications relating to the Host/Microbiome interaction. He is a Research Director at INRA (France’s National Institute for Agricultural Research) and Scientific Director of MetaGenoPolis. He brings more than 30 years of research in the Microbiome field.

PhD in Intestinal Microbiology

Pr Mohamad Mohty

Medical Hematology-Oncology Advisor – Co founder

Mohamad is a full Professor, Head of the Hematology and Cellular Therapy Department at Saint-Antoine Hospital and Sorbonne University. He is the former president of the EBMT (European Society for Blood and Marrow Transplantation). He has issued more than 500 publications relating to hematological malignancies.

MD, PhD, EBMT, ASBMT, EHA, ASH, ASCO

Our Board Of Directors.

Jean-Marie Lefevre

Chairman of the Board – Non-Executive Director

Jean-Marie has been President and CEO of Biocodex. He steered the creation of the “Biocodex Microbiota Institute” supporting innovative projects from Microbiota researchers. Jean-Marie has a long-track record of CEO positions amongst international firms such as LVMH or Bongrain.

Engineering from Ecole Centrale Paris, MBA from Insead

Our Board Of Directors.

Dr Pierre Belichard

Non-Executive Director – Co founder

As a co-founder of MaaT Pharma, Pierre is a serial entrepreneur who co-founded Enterome Bioscience, a pioneer from the Microbiome industry. Previously he co-founded Fovea Pharmaceuticals which was sold to Sanofi where he became the VP M&A and Business Development at Sanofi Ophthalmology.

PharmD, PhD, MBA from INSEAD

Isabelle de Crémoux

Non-Executive Director

Isabelle is CEO and Managing Partner of Seventure Partners. Prior to joining Seventure, she managed multiple international deals at Fournier/Abbott and Pfizer. Being visionary, she launched Health for Life Capital™, the first European investment vehicle to support the microbiome revolution.

Engineering from Ecole Centrale Paris

Dr Eric de la Fortelle

Non-Executive Director

Eric is a Venture Partner in the Life Sciences Team at Seventure Partners, specializing in Microbiome investments. Prior to joining Seventure, Eric was CEO of Delenex Therapeutics, a Zurich-based biotechnology company, sold to Cell Medica.

Engineering from Ecole Centrale Paris, MBA from Insead, PhD

Karine Lignel

Non-Executive Director

Karine is the CEO of CM-CIC Innovation, which has an active portfolio of 35 companies. She specializes in technological company investment and she brings almost 20 years of investment experience.

Engineer ENSIA, MBA in Finance and Accounting

Hervé Affagard

Chief Executive Officer – Co founder

As an entrepreneur in residence, Hervé has led MaaT Pharma since its inception phase in 2014. Notably, he was awarded Entrepreneur of the Year in Healthcare (2016) in recognition of his outstanding contribution to the development of MaaT Pharma.

Engineer, Executive MBA, Certificate “Exploring your Microbiome”, Francebiotech

Julien Samson

Independent Non-Executive Director

Julien is the General Manager of GlaxoSmithKline Korea. Previously he was appointed Vice-President – Commercial Operations Pharmaceuticals for the global respiratory franchise at GSK. Prior to joining GSK in 2012, Samson worked at France’s public hospitals and government agencies.

ENA (Ecole Nationale d’Administration)

Stéphanie Mercier-Arrabal

Censor

Stephanie is the Licensing Manager at INRA Transfer as well as the Deputy Director of the Carnot Institute Qualiment. She has supported several spin-off creations from INRA and brings almost 15 years of experience in translation science deals.

PhD, Master’s Degree

Our Partnerships 

Partnering with MaaT Pharma
to accelerate the access of our drugs to patients.

We are constantly looking to explore new frontiers, improve our drugs and improve the preparation of our clinical trials. Therefore, we are open to partnerships with investigator-initiated studies to collect Big Data using our Gut Print meta genomics platform.