We are building a leading microbiome company

MaaT Pharma has established several strong business partnerships. We have developed an efficient academic-industry translational collaboration with two entities from INRA (Institut National de la Recherche Agronomique or French National Institute for Agricultural Research): Micalis and MetaGenoPolis to design our proprietary MaaT Microbiome Restoration Platform which is the engine of our drug development platform. We also established a partnership with Biocodex in the area of oral formulation development. These two collaborations have led to the filing of 8 patent families and 1 patent in-license agreement.

The microbiome industry is emerging, especially the notion of developing therapeutics sourced from gut microbiota. As of today, there are three main approaches: Fecal microbiotherapy (via enteral or oral adminstration), microbiota modulators (agonists or antagonists) or molecules mimicking microbial components or products. We compete in the field of developing drugs based on the concept of fecal microbiotherapy using a unique pooled technology allowing very high diversity restoration. This approach has showed the highest efficacy in the therapeutic area of Clostridium difficile.

We have been working in coordination with the French regulatory agency (ANSM) since we designed our initial clinical development program framework in 2014 aiming at evaluating our microbiota-based drugs. Since then, we have extended our discussions at the EMA level as well as local competent national authorities and the FDA, in the USA. As for our medical devices, they were developed in line with the 93/42/CEE directive. We intend to obtain a CE marking for all our devices. To date, our collection device is CE marked, whereas the certification for our class II storage bag and accessories is expected by Q1 -2019.

MaaT Pharma targets to develop products that would be primarily prescribed by physicians in hospitals. We have, to date, completed several clinical trials that were conducted in 12 different hospitals in France where we initially assessed our drug candidates. We are now expanding geographically to 20 additional hospitals in Europe thanks to our clinical trial in acute GvHD.

We are located in the Gerland Biodistrict in Lyon, a vibrant ecosystem composed of leading businesses, SMEs and start-ups, research laboratories, universities and elite institutions, where we have established successful partnerships. We are also a member of the Lyonbiopole Cluster, the gateway to healthcare innovation in the Auvergne-Rhône-Alpes region.

Since our foundation in December 2014, Seventure, a subsidiary of Natixis and the first European fund devoted to microbiome investments “Health for Life”, has been a shareholder along with CM-CIC Innovation, one of the leading financers in high tech companies in France, Biocodex, an independent multinational pharmaceutical leader focused initially on probiotics, and finally the National Institute for Agricultural Research (INRA,) one of the leading academic centers in the field of Microbiota. As of March 2018, MaaT Pharma has raised 12 m€ in equity and 5+ m€ in non-dilutive funding thanks to the support from Bpifrance and our banking pool CIC and BNP Paribas.